HollisterStier Contract Manufacturing Signs Agreement with Prism Pharmaceuticals, Inc.

April 4, 2006. HollisterStier Contract Manufacturing, a leading manufacturer of high quality sterile injectable products for the global pharmaceutical and biopharmaceutical markets, has signed a Letter of Intent with Prism Pharmaceuticals, Inc. to develop a process for compounding and fill/finishing Prism’s PM101, an acute care cardiovascular drug. HollisterStier is producing PM101 registration material for clinical trials and is supporting Prism Pharmaceuticals filing of a New Drug Application (NDA). PM101 will be filled into vials and syringes.

Anthony Bonanzino, PhD, President and CEO of HollisterStier said, “HollisterStier is pleased to partner with Prism Pharmaceuticals on the development of this cardiovascular drug.  HollisterStier’s history of providing high quality service to our clients inevitably allows us to lower the development risk for companies like Prism. We provide a multifunctional team dedicated to solving their project goals quickly, which enables Prism to reduce the time to market.”

Kathleen DeLawrence, Vice President and COO of Prism Pharmaceuticals Inc., said, “We are pleased to be working with such an experienced contract manufacturer on our initial product development program. The team that HollisterStier has assembled to support our program is very experienced and committed to meeting our expectations for speed and excellence in execution.”

About HollisterStier
HollisterStier is a customer centric group of professionals dedicated to the contract manufacture of high quality sterile injectables for the global pharmaceutical and biopharmaceutical market. Our multidisciplinary teams provide custom solutions to customer specific project goals from development through commercialization. Based in Spokane, Washington, the company is committed to meeting customer expectations in all aspects of our business from quality manufacturing to regulatory support. For further information, visit www.hollisterstier.com.

About Prism Pharmaceuticals, Inc.
Based in King of Prussia, Pennsylvania, Prism Pharmaceuticals, Inc. is a specialty pharmaceutical company committed to developing and commercializing acute care cardiovascular products. For further information, visit www.prismpharma.com.

CONTACT: HollisterStier Contract Manufacturing
Janelle Jovick
(509) 482-0586 or
jjovick@hollister-stier.com

CONTACT:  Prism Pharmaceuticals, Inc.
Kathleen DeLawrence
(610) 265-7707 or
kdelawrence@prismpharma.com